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Risperidone

From Wikipedia
risperidone
type of chemical entity
Subclass ofheterocyclic compound Edit
Part ofresponse to risperidone Edit
Get useMedication Edit
Stylized namerisperiDONE, RisperDAL Edit
Chemical formulaC₂₃H₂₇FN₄O₂ Edit
Canonical SMILESCC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F Edit
Active ingredient inRisperdal Edit
World Health Organisation international non-proprietary namerisperidone Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category B3, US pregnancy category C Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category C Edit

Risperidone, dem sell under de brand name Risperdal among odas, be an atypical antipsychotic[1] dem use to treat schizophrenia den bipolar disorder,[1] as well as aggressive den self-injurious behaviors wey be associated plus autism spectrum disorder.[2] Dem dey take am either by mouth anaa by injection (i.e., subcutaneous anaa intramuscular).[1] De injectable versions be long-acting den dey last for 2–4 weeks.[3]

Common side effects dey include weight gain, drowsiness, fatigue, insomnia, dry mouth, constipation, elevated prolactin levels, den restlessness.[1][4] Serious side effects fi include de potentially permanent movement disorder tardive dyskinesia, as well as neuroleptic malignant syndrome, an increased risk of suicide, den high blood sugar levels.[1][3] Insyd older people plus psychosis as a result of dementia, e fi increase de risk of death.[1] E be unknown if e be safe for use insyd pregnancy.[1] Ein mechanism of action no be entirely clear, buh dem dey believe to be related to ein action as a dopamine den serotonin antagonist.[1]

Study of risperidone begin insyd de late 1980s wey dem approve for sale insyd de United States insyd 1993.[1][5][6] E be on de World Health Organization's List of Essential Medicines.[7] E be available as a generic medication.[3] Insyd 2023, e be de 176th most commonly prescribed medication insyd de United States, plus more dan 2 million prescriptions.[8][9]

References

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  1. 1 2 3 4 5 6 7 8 9 "Risperidone". The American Society of Health-System Pharmacists. Archived from the original on 2 December 2015. Retrieved 1 December 2015.
  2. ↑ Schatzberg AF, Nemeroff CB (2009). The American Psychiatric Publishing textbook of psychopharmacology (4th ed.). Washington, D.C.: American Psychiatric Pub. p. 627. ISBN 978-1-58562-309-9.
  3. 1 2 3 Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. pp. 434–435. ISBN 978-1-284-05756-0.
  4. ↑ Hasnain M, Vieweg WV, Hollett B (July 2012). "Weight gain and glucose dysregulation with second-generation antipsychotics and antidepressants: a review for primary care physicians". Postgraduate Medicine. 124 (4): 154–67. doi:10.3810/pgm.2012.07.2577. PMID 22913904. S2CID 39697130.
  5. ↑ Schatzberg AF, Nemeroff CB (2009). The American Psychiatric Publishing textbook of psychopharmacology (4th ed.). Washington, D.C.: American Psychiatric Pub. p. 627. ISBN 978-1-58562-309-9.
  6. ↑ "Risperdal- risperidone tablet Risperdal M-Tab- risperidone tablet, orally disintegrating Risperdal- risperidone solution". DailyMed. Archived from the original on 30 April 2017. Retrieved 31 December 2019.
  7. ↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  8. ↑ "The Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 13 August 2025.
  9. ↑ "Risperidone Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 13 August 2025.

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