Rosuvastatin
| Subclass of | statin, carboxylic acid  |
|---|---|
| Get use | Medication |
| Stereoisomer of | (3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-yl-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid, (E,3R,5R)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid |
| Chemical formula | C₂₂H₂₈FN₃O₆S |
| Canonical SMILES | CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C |
| Isomeric SMILES | CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C |
| Active ingredient in | Crestor |
| World Health Organisation international non-proprietary name | rosuvastatin |
| Physically dey interact plus | 3-hydroxy-3-methylglutaryl-CoA reductase |
| Pregnancy category | Australian pregnancy category D, US pregnancy category X |
| LiverTox likelihood score | LiverTox toxicity likelihood category B |
| Subject has role | statin |
Rosuvastatin, dem sell under de brand name Crestor among odas, be a statin medication, dem use to prevent cardiovascular disease insyd those at high risk den treat abnormal lipids.[1] E be recommended to be used plus dietary changes, exercise, den weight loss.[1] Dem dey take am orally (by mouth).[1]
Common side effects dey include abdominal pain, nausea, headaches, den muscle pains.[1] Serious side effects fi include rhabdomyolysis, liver problems, den diabetes.[1] Ein use during pregnancy fi harm de baby.[1] Like all statins, rosuvastatin dey work by inhibiting HMG-CoA reductase, an enzyme dem find insyd de liver wey dey play a role in producing cholesterol.[1]
Na dem patent rosuvastatin insyd 1991 wey na dem approve am for medical use insyd de United States insyd 2003.[1][2] E be available as a generic medication.[1] Insyd 2023, na e be de twelfth most commonly prescribed medication insyd de United States, plus more dan 42 million prescriptions.[3][4] Insyd Australia, na e be one of de top 10 most prescribed medications between 2017 den 2023.[5]
References
[edit | edit source]- 1 2 3 4 5 6 7 8 9 "Rosuvastatin Calcium Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists (AHFS). Archived from the original on 24 December 2018. Retrieved 24 December 2018.
- ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 473. ISBN 978-3-527-60749-5. Archived from the original on 12 January 2023. Retrieved 27 August 2020.
- ↑ "The Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Rosuvastatin Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 17 August 2025.
- ↑ "Medicines in the health system". Australian Institute of Health and Welfare. 2 July 2024. Retrieved 30 September 2024.
External links
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