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Sertraline

From Wikipedia
sertraline
type of chemical entity
Subclass of4-(3,4-Dichlorophenyl)-n-methyl-1,2,3,4-tetrahydronaphthalen-1-amine Edit
Get useMedication Edit
Stereoisomer ofcis-(-)-sertraline, (1S,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, trans-(+/-)-sertraline Edit
Chemical formulaC₁₇H₁₇Cl₂N Edit
Canonical SMILESCNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl Edit
Isomeric SMILESCN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl Edit
Active ingredient inZoloft Edit
World Health Organisation international non-proprietary namesertraline Edit
Physically dey interact plussolute carrier family 6 member 4 Edit
Pregnancy categoryAustralian pregnancy category C, US pregnancy category C Edit
Subject has roleselective serotonin reuptake inhibitor, antidepressant Edit

Sertraline, dem sell under de brand name Zoloft among odas, be an antidepressant medication of de selective serotonin reuptake inhibitor (SSRI) class[1] dem use to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, den premenstrual dysphoric disorder.[2] Although e sanso get approval for post-traumatic stress disorder (PTSD), findings dey indicate e dey lead to modest improvements per insyd symptoms dem associate plus dis condition.[3][4]

De drug dey share de common side effects den contraindications of oda SSRIs, plus high rates of nausea, diarrhea, headache, insomnia, mild sedation, dry mouth, den sexual dysfunction, buh e dey appear e no dey lead to much weight gain, den ein effects on cognitive performance be mild. Similar to oda antidepressants, de use of sertraline for depression fi be associated plus a mildly elevated rate of suicidal thoughts insyd people under de age of 25 years old. Dem for no use am togeda plus monoamine oxidase inhibitors (MAOIs): dis combination fi cause serotonin syndrome, wich fi be life-threatening insyd sam cases. Sertraline dem take during pregnancy be associated plus an increase insyd congenital heart defects insyd newborns.[5][6]

Na scientists at Pfizer develop sertraline wey dem approve am for medical use insyd de United States insyd 1991. E dey on de World Health Organization's List of Essential Medicines[7] wey e be available as a generic medication.[8] Insyd 2016, na sertraline be de most commonly prescribed psychotropic medication insyd de United States.[9] Na e sanso be de eleventh most commonly prescribed medication insyd de United States, plus more dan 42 million prescriptions insyd 2023,[10][11] wey sertraline dey rank among de top 10 most prescribed medications insyd Australia between 2017 den 2023.[12]

Sertraline ein effectiveness be similar to dat of oda antidepressants insyd ein class, such as fluoxetine den paroxetine, wich dem sanso consider first-line treatments wey dem be better tolerated dan de older tricyclic antidepressants.

References

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  1. ↑ "Sertraline Hydrochloride". Drugs.com. The American Society of Health-System Pharmacists. Retrieved 8 January 2018.
  2. ↑ Yonkers KA, Kornstein SG, Gueorguieva R, Merry B, Van Steenburgh K, Altemus M (October 2015). "Symptom-Onset Dosing of Sertraline for the Treatment of Premenstrual Dysphoric Disorder: A Randomized Clinical Trial". JAMA Psychiatry. 72 (10): 1037–1044. doi:10.1001/jamapsychiatry.2015.1472. PMC 4811029. PMID 26351969.
  3. ↑ Hoskins M, Pearce J, Bethell A, Dankova L, Barbui C, Tol WA, van Ommeren M, de Jong J, Seedat S, Chen H, Bisson JI (February 2015). "Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis". Br J Psychiatry. 206 (2): 93–100. doi:10.1192/bjp.bp.114.148551. PMID 25644881.
  4. ↑ Lee DJ, Schnitzlein CW, Wolf JP, Vythilingam M, Rasmusson AM, Hoge CW (September 2016). "Psychotherapy Versus Pharmacotherapy for Posttraumatic Stress Disorder: Systemic Review and Meta-Analyses to Determine First-Line Treatments". Depression and Anxiety. 33 (9): 792–806. doi:10.1002/da.22511. PMID 27126398. S2CID 20190202.
  5. ↑ Gao SY, Wu QJ, Sun C, Zhang TN, Shen ZQ, Liu CX, Gong TT, Xu X, Ji C, Huang DH, Chang Q, Zhao YH (November 2018). "Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births". BMC Med. 16 (1) 205. doi:10.1186/s12916-018-1193-5. PMC 6231277. PMID 30415641.
  6. ↑ De Vries C, Gadzhanova S, Sykes MJ, Ward M, Roughead E (March 2021). "A Systematic Review and Meta-Analysis Considering the Risk for Congenital Heart Defects of Antidepressant Classes and Individual Antidepressants". Drug Saf. 44 (3): 291–312. doi:10.1007/s40264-020-01027-x. ISSN 0114-5916. PMID 33354752. S2CID 229357583.
  7. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  8. ↑ "Sertraline Hydrochloride". Drugs.com. The American Society of Health-System Pharmacists. Retrieved 8 January 2018.
  9. ↑ Grohol JM (12 October 2017). "Top 25 Psychiatric Medications for 2016". Psych Central. Retrieved 22 October 2018.
  10. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  11. ↑ "Sertraline Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 12 August 2025.
  12. ↑ "Medicines in the health system". Australian Institute of Health and Welfare. 2 July 2024. Retrieved 30 September 2024.
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