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Sildenafil

From Wikipedia
sildenafil
type of chemical entity
Subclass ofchemical compound Edit
Get useMedication, lifestyle drug Edit
Chemical formulaC₂₂H₃₀N₆O₄S Edit
Canonical SMILESCCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C Edit
World Health Organisation international non-proprietary namesildenafil Edit
Medical condition treatedvasculogenic impotence, pulmonary hypertension, erectile dysfunction Edit
Route of administrationoral administration Edit
Pregnancy categoryAustralian pregnancy category B1, US pregnancy category B Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category C Edit
Subject has rolePDE5 inhibitor Edit

Sildenafil, dem sell under de brand name Viagra among odas, be a medication dem use to treat erectile dysfunction den pulmonary arterial hypertension.[1][2] E sanso sam times be used off-label for de treatment of certain symptoms insyd secondary Raynaud's phenomenon.[3] E be unclear if e be effective for treating sexual dysfunction insyd females.[2] Dem fi take am orally (dem swallow by mouth), intravenously (injection into a vein), anaa thru de sublingual route (dem dissolve under de tongue).[2][4] Onset wen dem take am orally be typically within twenty minutes den dey last for about two hours.[2]

Common side effects dey include headaches, heartburn, den flushed skin.[2] Caution be advised insyd those plus cardiovascular disease.[2] Rare buh serious side effects dey include vision problems, hearing loss, den prolonged erection (priapism) wey fi lead to damage to de penis.[2] Sildenafil for no be taken by people on nitric oxide donors such as nitroglycerin, as dis fi result in a serious drop in blood pressure.[2]

Sildenafil dey act by blocking phosphodiesterase 5 (PDE5), an enzyme wey dey promote breakdown of cGMP, wich dey regulate blood flow insyd de penis.[2] E dey require sexual arousal to work, den no dey by einself cause anaa increase sexual arousal.[2] E sanso dey result in dilation of de blood vessels insyd de lungs.[2]

Na Pfizer originally discover de medication insyd 1989 while dem dey look for a treatment give angina.[5] Na dem approve am for medical use insyd de United States den insyd de European Union insyd 1998.[2][5][6] Insyd 2023, na e be de 151st most commonly prescribed medication insyd de United States, plus more dan 3 million prescriptions.[7][8] E be available as a generic medication.[9][10] Insyd de United Kingdom, e be available as a pharmacy medicine.[11]

References

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  1. ↑ "Viagra- sildenafil citrate tablet, film coated". DailyMed. Archived from the original on 13 August 2020. Retrieved 6 October 2020.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 "Sildenafil Citrate". The American Society of Health-System Pharmacists. Archived from the original on 23 April 2020. Retrieved 1 December 2014.
  3. ↑ Roustit M, Blaise S, Allanore Y, Carpentier PH, Caglayan E, Cracowski JL (October 2013). "Phosphodiesterase-5 inhibitors for the treatment of secondary Raynaud's phenomenon: systematic review and meta-analysis of randomised trials". Annals of the Rheumatic Diseases. 72 (10): 1696–9. doi:10.1136/annrheumdis-2012-202836. PMID 23426043. S2CID 33666968. PDE-5 inhibitors appear to have significant but moderate efficacy in secondary [Raynaud's phenomenon].
  4. ↑ Deveci S, Peşkircioğlu L, Aygün C, Tekin MI, Dirim A, Ozkardeş H (November 2004). "Sublingual sildenafil in the treatment of erectile dysfunction: faster onset of action with less dose". International Journal of Urology. 11 (11): 989–92. doi:10.1111/j.1442-2042.2004.00933.x. PMID 15509203. S2CID 28302024.
  5. 1 2 Goldstein I, Burnett AL, Rosen RC, Park PW, Stecher VJ (January 2019). "The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction". Sexual Medicine Reviews. 7 (1): 115–128. doi:10.1016/j.sxmr.2018.06.005. PMID 30301707. S2CID 52945888.
  6. ↑ "Drug Approval Package: Viagra (sildenafil citrate) NDA #020895". U.S. Food and Drug Administration (FDA). 27 March 1998. Archived from the original on 31 March 2021. Retrieved 15 February 2021.
  7. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  8. ↑ "Sildenafil Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
  9. ↑ Gordon S (11 December 2017). "Generic Viagra: Two versions of sildenafil hit the market today". CBS News. Archived from the original on 25 November 2018. Retrieved 24 November 2018.
  10. ↑ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 3 March 2023. Archived from the original on 12 February 2022. Retrieved 6 March 2023.
  11. ↑ LaMattina J. "With Viagra Now Available Over-The-Counter In The U.K., Will The U.S. Follow Suit?". Forbes. Archived from the original on 25 November 2018. Retrieved 24 November 2018.
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