Temazepam
| Subclass of | chemical compound  |
|---|---|
| Get use | Medication |
| Chemical formula | C₁₆H₁₃ClN₂O₂ |
| Canonical SMILES | CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3 |
| Active ingredient in | Restoril |
| World Health Organisation international non-proprietary name | temazepam |
| Medical condition treated | anxiety disorder, panic disorder, insomnia, neurotic disorder, sleep-wake disorder |
| Pregnancy category | Australian pregnancy category C, US pregnancy category X |
| LiverTox likelihood score | LiverTox toxicity likelihood category E |
| MCN code | 2933.91.81 |
Temazepam, dem sell under de brand name Restoril among odas, be a medication of de benzodiazepine class wich generally be used to treat severe anaa debilitating insomnia.[1] Dem dey take am by mouth.[1] Temazepam rapidly be absorbed, den significant hypnotic den anxiolytic effects dey begin in less dan 30 minutes wey fi last for up to eight hours.[2][3] Prescriptions give hypnotics, such as temazepam, see a dramatic decrease since 2010, while anxiolytics, such as alprazolam, clonazepam, den lorazepam, increase anaa remain stable.[4] Temazepam den similar hypnotics, such as triazolam (Halcion), generally be reserved give severe den debilitating insomnia. Dem largely be replaced by z-drugs (zopiclone, zolpidem) den atypical antidepressants (trazodone, mirtazapine) as first line treatment give insomnia.[1]
Common side effects dey include drowsiness, motor den cognitive impairment, lethargy, confusion, euphoria, den dizziness.[1] Serious side effects fi include hallucinations, hypotension, respiratory depression, den anaphylaxis. E fi lead to addiction, wey e get a potential for abuse.[1] Ein use generally no be recommended togeda plus alcohol anaa opioids.[1] If de dose be rapidly decreased withdrawal fi occur.[1] Ein use during pregnancy anaa breastfeeding no be recommended.[5] Temazepam be a short-acting benzodiazepine den hypnotic.[1][3] E dey work by affecting GABA within de brain.[1]
Dem patent temazepam insyd 1962 wey e cam into medical use insyd 1969.[6] E be available as a generic medication.[7] Insyd 2021, na e be de 208th most commonly prescribed medication insyd de United States, plus more dan 2 million prescriptions.[8][9]
Overdose
[edit | edit source]Overdosage of temazepam dey result in increasing CNS effects, wey dey include:
- Somnolence (difficulty staying awake)
- Mental confusion
- Respiratory depression
- Hypotension
- Cyanosis
- Impaired motor functions
- Impaired or absent reflexes
- Impaired coordination
- Impaired balance
- Dizziness, sedation
- Coma
- Death
Street terms
[edit | edit source]Street terms give temazepam dey include king kong pills (dem formerly refer to barbiturates, now more commonly dey refer to temazepam), jellies, jelly, Edinburgh eccies, tams, terms, mazzies, temazies, tammies, temmies, beans, eggs, green eggs, wobbly eggs, knockouts, hardball, norries, oranges (common term insyd Australia den New Zealand), rugby balls, ruggers, terminators, red and blue, no-gos, num nums, blackout, green devils, drunk pills, brainwash, mind erasers, neurotrashers, tem-tems (dem combine plus buprenorphine), mommy's big helper, vitamin T, big T, TZ, de mazepam, resties (North America) den odas.[10][11]
References
[edit | edit source]- 1 2 3 4 5 6 7 8 9 "Temazepam Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 8 April 2019.
- ↑ "RESTORIL® Novartis Temazepam Hypnotic". Pharmaceutical Information. RxMed.
- 1 2 Collins SR (2015). Pharmacology and the Nursing Process. Elsevier Health Sciences. p. 193. ISBN 9780323358286.
- ↑ Breen CL, Degenhardt LJ, Bruno RB, Roxburgh AD, Jenkinson R (September 2004). "The effects of restricting publicly subsidised temazepam capsules on benzodiazepine use among injecting drug users in Australia". The Medical Journal of Australia. 181 (6): 300–304. doi:10.5694/j.1326-5377.2004.tb06293.x. PMID 15377238. S2CID 6870892.
- ↑ "Temazepam (Restoril) Use During Pregnancy". Drugs.com. Retrieved 8 April 2019.
- ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 537. ISBN 9783527607495.
- ↑ British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 481. ISBN 9780857113382.
- ↑ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ↑ "Temazepam - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ↑ "DAN 24/7: Temazepam". www.dan247.org.uk. Archived from the original on 5 July 2018. Retrieved 4 July 2018.
- ↑ "Erowid Drug Street Terms". Erowid.
External links
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