Tizanidine
| Subclass of | heterocyclic compound  |
|---|---|
| Get use | Medication |
| Stylized name | tiZANidine |
| Chemical formula | C₉H₈ClN₅S |
| Canonical SMILES | C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl |
| Active ingredient in | Zanaflex |
| World Health Organisation international non-proprietary name | tizanidine |
| LiverTox likelihood score | LiverTox toxicity likelihood category C |
| Subject has role | Adrenergic alpha-2 Receptor Agonists, analgesic, anticonvulsant agent, central muscle relaxants, parasympatholytic |
Tizanidine, dem sell under de brand name Zanaflex among odas, be an alpha-2 (α2) adrenergic receptor agonist,[1] similar to clonidine, wey be used to treat muscle spasticity secof spinal cord injury, multiple sclerosis, den spastic cerebral palsy.[2] Effectiveness dey appear similar to baclofen anaa diazepam.[3] Dem dey take am by mouth.[4]
Common side effects of tizanidine dey include dry mouth, sleepiness, weakness, den dizziness.[5] Serious side effects fi include low blood pressure, liver problems, psychosis, den QT prolongation.[5] E be unclear if use insyd pregnancy den breastfeeding be safe.[6] E be an α2-adrenergic agonist, buh how e dey work no be entirely clear.[5]
Na dem approve tizanidine for medical use insyd de United States insyd 1996.[5] E be available as a generic medication.[2] Insyd 2023, na e be de 81st most commonly prescribed medication insyd de United States, plus more dan 8 million prescriptions.[7][8]
References
[edit | edit source]- ↑ Katzung BG (30 November 2017). Basic & clinical pharmacology (14th ed.). New York: McGraw Hill Education. p. 487. ISBN 9781259641152. OCLC 1015240036.
- 1 2 British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1094. ISBN 9780857113382.
- ↑ Kamen L, Henney HR, Runyan JD (February 2008). "A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury". Current Medical Research and Opinion. 24 (2): 425–439. doi:10.1185/030079908X261113. PMID 18167175. S2CID 73086671.
- ↑ "Tizanidine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
- 1 2 3 4 "Tizanidine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
- ↑ "Tizanidine Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
- ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Tizanidine Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
External links
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