Trazodone

type of chemical entity
Subclass of	chemical compound
Get use	Medication
Stylized name	traZODone
Chemical formula	C₁₉H₂₂ClN₅O
Canonical SMILES	C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
World Health Organisation international non-proprietary name	trazodone
Medical condition treated	insomnia, neurotic disorder, anxiety, sleep-wake disorder, delirium
Physically dey interact plus	5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C
Legal status (medicine)	boxed warning
Pregnancy category	US pregnancy category C
Subject has role	selective serotonin reuptake inhibitor, H1 antagonist, anxiolytic, second-generation antidepressive agents

Trazodone be an antidepressant medication^[1] dem use to treat major depressive disorder, anxiety disorders, den insomnia.^[1] E be a phenylpiperazine compound of de serotonin antagonist and reuptake inhibitor (SARI) class.^[2]^[3] Dem dey take de medication orally.^[1]

Common side effects dey include dry mouth, feeling faint, vomiting, den headache.^[1] More serious side effects fi include suicide, mania, irregular heart rate, den pathologically prolonged erections.^[1] E be unclear if ein use during pregnancy anaa breastfeeding be safe.^[4] Trazodone sanso get sedating effects.^[5]

Na dem approve trazodone for medical use insyd de United States insyd 1981.^[1] E be available as a generic medication.^[1] Insyd 2023, na e be de 21st most commonly medication dem prescribe insyd de United States den de fifth most common antidepressant, plus more dan 24 million prescriptions.^[6]^[7]

References

1 2 3 4 5 6 7 "Trazodone". The American Society of Health-System Pharmacists. 17 March 2021. Retrieved 24 December 2021.
↑ Stahl SM (2008). Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. Cambridge University Press. p. 567. ISBN 978-0-521-85702-4.
↑ Lemke TL, Williams DA (2008). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. p. 586. ISBN 978-0-7817-6879-5.
↑ "Trazodone Use During Pregnancy". Drugs.com. Retrieved 7 January 2018.
↑ British national formulary: BNF 69 (69th ed.). British Medical Association. 2015. pp. 257–58. ISBN 978-0-85711-156-2.
↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
↑ "Trazodone Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 17 August 2025.

External links

[AHFS20213-1] 1 2 3 4 5 6 7 "Trazodone". The American Society of Health-System Pharmacists. 17 March 2021. Retrieved 24 December 2021.

[2] Stahl SM (2008). Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. Cambridge University Press. p. 567. ISBN 978-0-521-85702-4.

[3] Lemke TL, Williams DA (2008). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. p. 586. ISBN 978-0-7817-6879-5.

[4] "Trazodone Use During Pregnancy". Drugs.com. Retrieved 7 January 2018.

[BNF69-5] British national formulary: BNF 69 (69th ed.). British Medical Association. 2015. pp. 257–58. ISBN 978-0-85711-156-2.

[Top300Drugs-6] "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.

[7] "Trazodone Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 17 August 2025.

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