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Ulcerative colitis

From Wikipedia
ulcerative colitis
designated intractable/rare disease, class of disease, signs den symptoms
Subclass ofcolitis, autoimmune disease of gastrointestinal tract, disease Edit
Health specialtygastroenterology Edit
External data available at URLhttp://www.nanbyou.or.jp/entry/62 Edit
ICD-9-CM556, 556.9, 556.5, 556.8 Edit
ICPC 2 IDD94 Edit
NCI Thesaurus IDC2952 Edit

Ulcerative colitis (UC) be one of de two types of inflammatory bowel disease (IBD), plus de oda type be Crohn's disease.[1] E be a long-term condition wey dey result in inflammation den ulcers of de colon den rectum.[1][2] De primary symptoms of active disease be abdominal pain den diarrhea mixed plus blood (hematochezia).[1] Weight loss, fever, den anemia sanso fi occur.[1] Often, symptoms cam on slowly wey fi range from mild to severe.[1] Symptoms typically dey occur intermittently plus periods of no symptoms between flares.[1] Complications fi include abnormal dilation of de colon (megacolon), inflammation of de eye, joints, anaa liver, den colon cancer.[1][3]

De cause of UC be unknown.[1] Theories dey involve immune system dysfunction, genetics, changes insyd de normal gut bacteria, den environmental factors.[1][4] Rates dey tend to be higher insyd de developed world plus sam dey propose dis to be de result of less exposure to intestinal infections, anaa to a Western diet den lifestyle.[2][5] De removal of de appendix at an early age fi be protective.[5] Diagnosis be typically by colonoscopy, a type of endoscopy, plus tissue biopsies.[1]

Dem dey use chaw medications to treat symptoms wey dey bring about den maintain remission, wey dey include aminosalicylates such as mesalazine anaa sulfasalazine, steroids, immunosuppressants such as azathioprine, den biologic therapy.[1] Removal of de colon by surgery fi be necessary if de disease be severe, wey no dey respond to treatment, anaa if na complications such as colon cancer develop.[1] Removal of de colon den rectum generally dey cure de condition.[1][5]

Notable cases

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References

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  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 "Ulcerative Colitis". NIDDK. September 2014. Retrieved 3 August 2016.
  2. 1 2 Ford AC, Moayyedi P, Hanauer SB (February 2013). "Ulcerative colitis". BMJ. 346: f432. doi:10.1136/bmj.f432. PMID 23386404. S2CID 14778938.
  3. ↑ Wanderås MH, Moum BA, Høivik ML, Hovde Ø (May 2016). "Predictive factors for a severe clinical course in ulcerative colitis: Results from population-based studies". World Journal of Gastrointestinal Pharmacology and Therapeutics. 7 (2): 235–241. doi:10.4292/wjgpt.v7.i2.235. PMC 4848246. PMID 27158539.
  4. ↑ Akiho H, Yokoyama A, Abe S, Nakazono Y, Murakami M, Otsuka Y, Fukawa K, Esaki M, Niina Y, Ogino H (November 2015). "Promising biological therapies for ulcerative colitis: A review of the literature". World Journal of Gastrointestinal Pathophysiology. 6 (4): 219–227. doi:10.4291/wjgp.v6.i4.219. PMC 4644886. PMID 26600980.
  5. 1 2 3 Danese S, Fiocchi C (November 2011). "Ulcerative colitis". The New England Journal of Medicine. 365 (18): 1713–1725. doi:10.1056/NEJMra1102942. PMID 22047562.
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