Variant Creutzfeldt–Jakob disease
| Subclass of | transmissible spongiform encephalopathy  |
|---|---|
| Short name | vCJD |
| Dem name after | Hans Gerhard Creutzfeldt |
| Health specialty | infectious diseases |
Variant Creutzfeldt–Jakob disease (vCJD), dem formerly know as new variant Creutzfeldt–Jakob disease (nvCJD) wey dem refer to am colloquially as "Creutzfeldt–Jakob Disease", "mad cow disease" anaa "human mad cow disease" (to distinguish am from ein BSE counterpart), be a fatal type of brain disease within de transmissible spongiform encephalopathy family.[1] Initial symptoms dey include psychiatric problems, behavioral changes, den painful sensations.[2] Insyd de later stages of de illness, patients fi exhibit poor coordination, dementia den involuntary movements.[3] De length of time between exposure den de development of symptoms be unclear, buh e be believed to be years to decades.[4] Average life expectancy dey follow de onset of symptoms be 13 months.[2]
E be caused by prions, wich be misfolded proteins.[5] Spread be believed to be primarily secof dem chop beef wey be infected plus BSE.[6][5] Infection sanso be believed to require a specific genetic susceptibility.[7][6] Spread potentially sanso fi occur via blood products anaa contaminated surgical equipment.[8] Diagnosis be by brain biopsy buh fi be suspected based on certain oda criteria.[4] E be different from typical Creutzfeldt–Jakob disease, though both be secof prions.[5]
Treatment give vCJD dey involve supportive care.[9] As of 2020, 178 cases of vCJD be recorded insyd de United Kingdom,[10] secof a 1990s outbreak, den 50 cases insyd de rest of de world.[6] De disease cam be less common since 2000.[6] De typical age of onset be less dan 30 years old.[4] E be first identified insyd 1996 by de National CJD Surveillance Unit insyd Edinburgh, Scotland.[6] Controversial research by Harash Narang, wey work as a virologist at de Public Health Laboratory Service (PHLS) suggest a link between BSE den CJD as early as 1989.[11][12]
References
[edit | edit source]- ↑ Ironside JW (2012). "Variant Creutzfeldt-Jakob disease: an update". Folia Neuropathologica. 50 (1): 50–56. PMID 22505363.
- 1 2 "Clinical and Pathologic Characteristics | Variant Creutzfeldt-Jakob Disease, Classic (CJD)". CDC (in American English). 10 February 2015. Retrieved 22 January 2018.
- ↑ "Clinical Overview of Variant Creutzfeldt-Jakob Disease". CDC (in American English). November 2012. Retrieved February 24, 2026.
- 1 2 3 "Classic CJD versus Variant CJD". CDC (in American English). 11 February 2015. Archived from the original on August 31, 2015. Retrieved 23 January 2018.
- 1 2 3 "About vCJD". CDC (in American English). 10 February 2015. Retrieved 22 January 2018.
- 1 2 3 4 5 Ironside JW (2012). "Variant Creutzfeldt-Jakob disease: an update". Folia Neuropathologica. 50 (1): 50–56. PMID 22505363.
- ↑ Ironside JW (July 2010). "Variant Creutzfeldt-Jakob disease". Haemophilia. 16 (Suppl 5): 175–180. doi:10.1111/j.1365-2516.2010.02317.x. PMID 20590878. S2CID 24635924.
- ↑ Ferri FF (2017). Ferri's Clinical Advisor 2018 E-Book: 5 Books in 1 (in English). Elsevier Health Sciences. p. 343. ISBN 9780323529570.
- ↑ "Treatment Variant Creutzfeldt-Jakob Disease". CDC (in American English). 10 February 2015. Retrieved 23 January 2018.
- ↑ Gill ON, Spencer Y, Richard-Loendt A, Kelly C, Brown D, Sinka K, et al. (June 2020). "Prevalence in Britain of abnormal prion protein in human appendices before and after exposure to the cattle BSE epizootic". Acta Neuropathologica. 139 (6): 965–976. doi:10.1007/s00401-020-02153-7. PMC 7244468. PMID 32232565.
- ↑ "How a scientist obtained thousands for a BSE test he could not prove". The Independent (in English). 1999-08-10. Retrieved 2026-03-18.
- ↑ "Thousands may have caught CJD during three years before Government clamped down on meat Deadly legacy of infection". The Herald (in English). 1996-03-21. Retrieved 2026-03-18.
External links
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